General Information

  • ID:  hor001636
  • Uniprot ID:  B3A052
  • Protein name:  Extended FMRFamide-12
  • Gene name:  NA
  • Organism:  Karoophasma botterkloofense (Gladiator) (Heel-walker)
  • Family:  FARP (FMRF amide related peptide) family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Karoophasma (genus), Austrophasmatidae (family), Mantophasmatodea (order), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  SPALDDERNDNFIRL
  • Length:  15(1-15)
  • Propeptide:  SPALDDERNDNFIRL
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  FMRFamides and FMRFamide-like peptides are neuropeptides.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor001636_AF2.pdbhor001636_ESM.pdb

Physical Information

Mass: 202481 Formula: C75H119N23O27
Absent amino acids: CGHKMQTVWY Common amino acids: D
pI: 4.06 Basic residues: 2
Polar residues: 3 Hydrophobic residues: 5
Hydrophobicity: -104.67 Boman Index: -5994
Half-Life / Aliphatic Index: 1.9 hour Aliphatic Index: 84.67
Instability Index: 4967.33 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  22508719
  • Title:  Peptidomics-based phylogeny and biogeography of Mantophasmatodea (Hexapoda).